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KMID : 1141520210360030697
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Endocrinology and Metabolism
2021 Volume.36 No. 3 p.697 ~ p.701
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Urinary Free Metanephrines for Diagnosis of Pheochromocytoma and Paraganglioma
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Ahn Ji-Yeon
Park Ji-Yun
Kim Gyu-Ri
Jin Sang-Man
Hur Kyu-Yeon
Lee Soo-Youn
Kim Jae-Hyeon
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Abstract
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Background: Pheochromocytoma and paraganglioma (PPGL) is diagnosed through biochemical confirmation of excessive catecholamines in urine and plasma. Recent technological developments have allowed us to measure urinary free metanephrines; however, the diagnostic accuracy of these new methods and the diagnostic cutoff values have not been evaluated.
Methods: This is a retrospective study of 595 subjects, including 71 PPGL cases and 524 controls. PPGL was based on pathological confirmation. Subjects with no evidence of PPGL over 2 years were included in the control group.
Results: Urinary free metanephrines yielded similar area under the curve (AUC) to urinary fractionated metanephrines and plasma free metanephrines. However, urinary free normetanephrine yielded a better AUC than did urinary fractionated normetanephrine. The optimal cutoff for urinary free metanephrine and normetanephrine corrected for urinary creatinine yielded 97.2% sensitivity and 98.1% specificity.
Conclusion: Urinary free metanephrines are a reliable method for diagnosing PPGL in Asian populations compared with existing biochemical methods.
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KEYWORD
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Metanephrine, Normetanephrine, Pheochromocytoma, Paraganglioma
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